The Physics of Cellular Decision Making during Epithelial-Mesenchymal Transition

Tripathi, S and Levine, H and Jolly, MK (2020) The Physics of Cellular Decision Making during Epithelial-Mesenchymal Transition. [Book Chapter]

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Abstract

The epithelial-mesenchymal transition (EMT) is a process by which cells lose epithelial traits, such as cell-cell adhesion and apico-basal polarity, and acquire migratory and invasive traits. EMT is crucial to embryonic development and wound healing. Misregulated EMT has been implicated in processes associated with cancer aggressiveness, including metastasis. Recent experimental advances such as single-cell analysis and temporal phenotypic characterization have established that EMT is a multistable process wherein cells exhibit and switch among multiple phenotypic states. This is in contrast to the classical perception of EMT as leading to a binary choice. Mathematical modeling has been at the forefront of this transformation for the field, not only providing a conceptual framework to integrate and analyze experimental data, but also making testable predictions. In this article, we review the key features and characteristics of EMT dynamics, with a focus on the mathematical modeling approaches that have been instrumental to obtaining various useful insights. © 2020 by Annual Reviews. All rights reserved.

Item Type:	Book Chapter
Publication:	Annual Review of Biophysics
Publisher:	Annual Reviews Inc.
Additional Information:	The copyright for this article belongs to Annual Reviews Inc.
Keywords:	cancer growth; cell communication; cell population; cell transformation; decision making; epigenetics; epithelial mesenchymal transition; extracellular matrix; human; hysteresis; mathematical model; mesenchymal epithelial transition; nonhuman; physics; priority journal; Review; signal transduction; biophysics; cells; cytology; metastasis; neoplasm; pathology, Biophysical Phenomena; Cells; Epithelial-Mesenchymal Transition; Humans; Neoplasm Metastasis; Neoplasms
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	06 Feb 2023 09:12
Last Modified:	06 Feb 2023 09:12
URI:	https://eprints.iisc.ac.in/id/eprint/79903

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