Narashimhan Ramana, L and Mudakavi, RJ and Raichur, AM (2020) Self-assembled albumin decorated MoS2aggregates and photo-stimuli induced geometrical switching for enhanced theranostics applications. In: Materials Advances, 1 (8). pp. 3000-3008.
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Abstract
2D materials such as graphene oxide and molybdenum sulfide exhibit certain properties such as photoluminescence, photothermal and photodynamic effects that have potential in diagnosing and treating cancer. However, their application is limited by low cellular uptake of the sheet-like structure. In this study, we present a facile route for converting MoS2 sheets into cotton-candy like aggregates which are then internalized easily by cells and then disassembled into sheets. Initially MoS2 sheets are produced from bulk MoS2 by albumin assisted exfoliation followed by assembly of sheets into aggregates by a desolvation technique. The MoS2 cotton-candy like aggregates can be taken up by cells more easily when compared to sheets because of low colloidal stability. Using a near infrared laser, the aggregates can be disintegrated into sheets within the cells. Two processes take place in this step. First, the photothermal properties of MoS2 aggregates can be used to kill cancerous cells. Secondly, on disintegration, the photoluminescence properties of MoS2 sheets can be utilized to image cancer cells. The cytotoxicity, phototoxicity and apoptosis of HeLa cells are reported here. A facile method for increasing the uptake of 2D materials into cells has been demonstrated.
| Item Type: | Journal Article |
|---|---|
| Publication: | Materials Advances |
| Publisher: | Royal Society of Chemistry |
| Additional Information: | The copyright for this article belongs to the Author(s). |
| Department/Centre: | Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy) |
| Date Deposited: | 23 Jan 2023 06:34 |
| Last Modified: | 23 Jan 2023 06:34 |
| URI: | https://eprints.iisc.ac.in/id/eprint/79253 |
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