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Surface-Coated Cerium Nanoparticles to Improve Chemotherapeutic Delivery to Tumor Cells

Pramanik, N and De, T and Sharma, P and Alakesh, A and Jagirdar, SK and Rangarajan, A and Jhunjhunwala, S (2022) Surface-Coated Cerium Nanoparticles to Improve Chemotherapeutic Delivery to Tumor Cells. In: ACS Omega .

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Official URL: https://doi.org/10.1021/acsomega.2c00062


The antioxidant property of cerium oxide nanoparticles has increased their demand as a nanocarrier to improve the delivery and therapeutic efficacy of anticancer drugs. Here, we report the synthesis of alginate-coated ceria nanoformulations (ceria NPs) and characterization using FTIR spectroscopy, Raman microscopy, and X-ray diffraction. The synthesized ceria NPs show negligible inherent in vitro toxicity when tested on a MDA-MB-231 breast cancer cell line at higher particle concentrations. Upon loading these particles with doxorubicin (Dox) and paclitaxel (PTX) drugs, we observe a potential synergistic cytotoxic effect mediated by the drug and the ceria NPs, resulting in the better killing capacity as well as suppression of cell migration against the MDA-MB-231 cell line. Further, to verify the immune-escaping capacity before targeting cancer cells, we coated the drug-loaded ceria NPs with the membrane of MDA-MB-231 cells using an extrusion method. The resultant delivery system exhibited in vitro preferential uptake by the MDA-MB-231 cell line and showed reduced uptake by the murine macrophage cell line (RAW 264.7), assigning its potential application as non-immunogenic personalized therapy in targeting and killing of cancer cells.

Item Type: Journal Article
Publication: ACS Omega
Publisher: American Chemical Society
Additional Information: The copyright for this article belongs to the Authors.
Department/Centre: Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 06 Oct 2022 11:15
Last Modified: 06 Oct 2022 11:15
URI: https://eprints.iisc.ac.in/id/eprint/77264

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