Prajapati, SK and Malaiya, A and Mishra, G and Jain, D and Kesharwani, P and Mody, N and Ahmadi, A and Paliwal, R and Jain, A (2022) An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations. In: Journal of Ethnopharmacology, 296 .
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Abstract
Ethnopharmacological relevance: The coronavirus disease (COVID-19) has relentlessly spread all over the world even after the advent of vaccines. It demands management, treatment, and prevention as well with utmost safety and effectiveness. It is well researched that herbal medicines or natural products have shown promising outcomes to strengthen immunity with antiviral potential against SARS-COV-2. Aim of the review: Our objective is to provide a comprehensive insight into the preventive and therapeutic effects of herbal medicines and products (Ayurvedic) for pre-and post-COVID manifestations. Material and method: The database used in the text is collected and compiled from Scopus, PubMed, Nature, Elsevier, Web of Science, bioRxiv, medRxiv, American Chemical Society, and clinicaltrials.gov up to January 2022. Articles from non-academic sources such as websites and news were also retrieved. Exploration of the studies was executed to recognize supplementary publications of research studies and systematic reviews. The keywords, such as “SARS-COV-2, coronavirus, COVID-19, herbal drugs, immunity, herbal immunomodulators, infection, herbal antiviral drugs, and WHO recommendation” were thoroughly searched. Chemical structures were drawn using the software Chemdraw Professional 15.0.0.160 (PerkinElmer Informatics, Inc.). Result: A plethora of literature supports that the use of herbal regimens not only strengthen immunity but can also treat SARS-COV-2 infection with minimal side effects. This review summarizes the mechanistic insights into herbal therapy engaging interferons and antibodies to boost the response against SARS-COV-2 infection, several clinical trials, and in silico studies (computational approaches) on selected natural products including, Ashwagandha, Guduchi, Yashtimadhu, Tulsi, etc. as preventive and therapeutic measures against COVID. We have also emphasized the exploitation of herbal medicine-based pharmaceutical products along with perspectives for unseen upcoming alike diseases. Conclusion: According to the current state of art and cutting-edge research on herbal medicines have showed a significant promise as modern COVID tools. Since vaccination cannot be purported as a long-term cure for viral infections, herbal/natural medicines can only be considered a viable alternative to current remedies, as conceived from our collected data to unroot recurring viral infections.
| Item Type: | Journal Article |
|---|---|
| Publication: | Journal of Ethnopharmacology |
| Publisher: | Elsevier Ireland Ltd |
| Additional Information: | The copyright for this article belongs to the Author(s). |
| Keywords: | antivirus agent; herbaceous agent, comprehension; drug therapy; human; medicinal plant, Antiviral Agents; Comprehension; COVID-19; Drugs, Chinese Herbal; Humans; Plants, Medicinal; SARS-CoV-2 |
| Department/Centre: | Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy) |
| Date Deposited: | 17 Sep 2022 03:28 |
| Last Modified: | 17 Sep 2022 03:28 |
| URI: | https://eprints.iisc.ac.in/id/eprint/76580 |
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