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Before the “cytokine storm”: Boosting efferocytosis as an effective strategy against SARS-CoV-2 infection and associated complications

Dutta, S and Mukherjee, A and Nongthomba, U (2022) Before the “cytokine storm”: Boosting efferocytosis as an effective strategy against SARS-CoV-2 infection and associated complications. In: Cytokine and Growth Factor Reviews, 63 . pp. 108-118.

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Official URL: https://doi.org/10.1016/j.cytogfr.2022.01.002


The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is responsible for the ongoing COVID-19 pandemic, and causes many health complications, including major lung diseases. Besides investigations into the virology of SARS-CoV-2, understanding the immunological routes underlying the clinical manifestations of COVID-19 is important for developing effective therapeutic interventions. The clearance of SARS-CoV-2-infected apoptotic cells by professional efferocytes, through a process termed as 'efferocytosis', is essential for maintaining tissue homeostasis, and reducing the chances of health complications caused by SARS-CoV-2 infection. In this review, we focus on the cellular events leading to engagement of the SARS-CoV-2 with type 2 alveolar cells, and how SARS-COV-2 infection impairs the macrophage anti-inflammatory programming. We also discuss accounts of impaired efferocytosis, and the “cytokine storm” which occur concomitantly with the SARS-CoV-2 infection. Finally, we propose how targeting impaired efferocytosis, due to the SARS-CoV-2 infection, may be a beneficial therapeutic strategy to combat COVID-19, and its complications.

Item Type: Journal Article
Publication: Cytokine and Growth Factor Reviews
Publisher: Elsevier Ltd
Additional Information: The copyright for this article belongs to the Elsevier Ltd.
Keywords: adult respiratory distress syndrome; apoptosis; autoimmune disease; coronavirus disease 2019; cytokine storm; diabetes mellitus; disease association; efferocytosis; human; infection complication; inflammation; lung alveolus cell type 2; lung disease; macrophage; nonhuman; nuclear reprogramming; phagocytosis; respiratory system; Review; Severe acute respiratory syndrome coronavirus 2; virus immunity; cytokine release syndrome; pandemic, COVID-19; Cytokine Release Syndrome; Humans; Macrophages; Pandemics; SARS-CoV-2
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 27 Jun 2022 05:50
Last Modified: 27 Jun 2022 05:50
URI: https://eprints.iisc.ac.in/id/eprint/73904

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