Injectable and self-healing double network polysaccharide hydrogel as a minimally-invasive delivery platform

Mondal, P and Chatterjee, K (2022) Injectable and self-healing double network polysaccharide hydrogel as a minimally-invasive delivery platform. In: Carbohydrate Polymers, 291 .

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Abstract

Injectable hydrogels exhibiting self-healing ability are promising carriers for controlled and sustained delivery in a minimally-invasive format for biomedical applications. We designed a polysaccharide-based double network hydrogel by mixing solutions of aldehyde-alginate (aAlg) and acrylic acid-chitosan (aCS) in the presence of adipic acid dihydrazide and FeCl2 that resulted in dual crosslinking mediated by Schiff base and ionic interactions. The hydrogel exhibited excellent thixotropic and self-healing properties with a high compressive fracture strength of ≈ 48 kPa. Encapsulated cells were viable within the hydrogel, and after their release from the degraded gel. The controlled release of Doxorubicin and Ciprofloxacin from the hydrogels established the gel as a delivery platform. The released drugs were effective in killing cancer cells or arresting the growth of both bacteria. This work presents a self-healing and injectable degradable hydrogel that may be used as a minimally-invasive platform for the delivery of drugs and cells.

Item Type:	Journal Article
Publication:	Carbohydrate Polymers
Publisher:	Elsevier Ltd
Additional Information:	The copyright for this article belongs to the Elsevier Ltd.
Keywords:	Chlorine compounds; Controlled drug delivery; Crosslinking; Fracture toughness; Hydrogels; Iron compounds; Medical applications; Targeted drug delivery, Adipic acids; Biomedical applications; Double-network hydrogels; Injectable hydrogels; Injectables; Minimally invasive; Polysaccharide hydrogels; Schiff-base; Self-healing; Self-healing abilities, Self-healing materials
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	15 Jun 2022 09:45
Last Modified:	15 Jun 2022 09:45
URI:	https://eprints.iisc.ac.in/id/eprint/73571

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