Chandra, Kasturi and Garai, Preeti and Chakravortty, Jayanta and Chakravortty, Dipshikha (2017) Peptide transporter YjiY influences the expression of the virulence gene mgtC to regulate biofilm formation in Salmonella. In: FEMS Microbiology Letters, 364 (24). ISSN 1574-6968
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Abstract
Formation of a biofilm is one of the coping strategies of Salmonella against antimicrobial environmental stresses including nutrient starvation. However, the channeling of the starvation cue towards biofilm formation is not well understood. Our study shows that a carbon starvation gene, yjiY, coding for a peptide transporter, influences the expression of a virulence-associated gene mgtC in Salmonella to regulate biofilm formation. We demonstrate here that the mutant strain yjiY is unable to form a biofilm due to the increased expression of mgtC. The upregulation of mgtC in the yjiY strain correlates with the downregulation of the biofilm master regulator gene, csgD, and reduced levels of ATP. Our work further indicates that a yjiY-encoded peptide transporter may regulate the expression of mgtC by transporting proline peptides.
| Item Type: | Journal Article |
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| Publication: | FEMS Microbiology Letters |
| Publisher: | Oxford University Press |
| Additional Information: | The copyright of this article belongs to the authors. |
| Keywords: | Biofilm; mgtC; peptide transporter; proline; Salmonella; starvation |
| Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit Division of Biological Sciences > Microbiology & Cell Biology Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering |
| Date Deposited: | 02 Jun 2022 06:24 |
| Last Modified: | 02 Jun 2022 06:24 |
| URI: | https://eprints.iisc.ac.in/id/eprint/73059 |
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