Opportunities in combinational chemo-immunotherapy for breast cancer using nanotechnology: an emerging landscape

Raikwar, S and Jain, A and Saraf, S and Bidla, PD and Panda, PK and Tiwari, A and Verma, A and Jain, SK (2022) Opportunities in combinational chemo-immunotherapy for breast cancer using nanotechnology: an emerging landscape. In: Expert Opinion on Drug Delivery, 19 (3). pp. 247-268.

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Abstract

Introduction: Breast carcinoma (BC) is one of the most frequent causes of cancer-related death among women, which is due to the poor response to conventional therapy. There are several complications associated with monotherapy for cancer, such as cytotoxicity to normal cells, multidrug resistance (MDR), side effects, and limited applications. To overcome these challenges, a combination of chemotherapy and immunotherapy (monoclonal antibodies, anticancer vaccines, checkpoint inhibitors, and cytokines) has been introduced. Drug delivery systems (DDSs) based on nanotechnology have more applications in BC treatment owing to their controlled and targeted drug release with lower toxicity and reduced adverse drug effects. Several nanocarriers, such as liposomes, nanoparticles, dendrimers, and micelles, have been used for the effective delivery of drugs. Areas covered: This article presents opportunities and challenges in BC treatment, the rationale for cancer immunotherapy, and several combinational approaches with their applications for BC treatment. Expert opinion: Nanotechnology can be used for the early prognosis and cure of BC. Several novel and targeted DDSs have been developed to enhance the efficacy of anticancer drugs. This article aims to understand new strategies for the treatment of BC and the appropriate design of nanocarriers used as a combinational DDS. © 2022 Informa UK Limited, trading as Taylor & Francis Group.

Item Type:	Journal Article
Publication:	Expert Opinion on Drug Delivery
Publisher:	Taylor and Francis Ltd.
Additional Information:	The copyright for this article belongs to Taylor and Francis Ltd.
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	14 May 2022 16:06
Last Modified:	20 May 2022 11:48
URI:	https://eprints.iisc.ac.in/id/eprint/71655

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