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Intrinsically Disordered Proteins: Critical Components of the Wetware

Kulkarni, P and Bhattacharya, S and Achuthan, S and Behal, A and Jolly, MK and Kotnala, S and Mohanty, A and Rangarajan, G and Salgia, R and Uversky, V (2022) Intrinsically Disordered Proteins: Critical Components of the Wetware. In: Chemical Reviews, 122 (6). pp. 6614-6633.

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Official URL: https://doi.org/10.1021/acs.chemrev.1c00848


Despite the wealth of knowledge gained about intrinsically disordered proteins (IDPs) since their discovery, there are several aspects that remain unexplored and, hence, poorly understood. A living cell is a complex adaptive system that can be described as a wetware-a metaphor used to describe the cell as a computer comprising both hardware and software and attuned to logic gates-capable of "making"decisions. In this focused Review, we discuss how IDPs, as critical components of the wetware, influence cell-fate decisions by wiring protein interaction networks to keep them minimally frustrated. Because IDPs lie between order and chaos, we explore the possibility that they can be modeled as attractors. Further, we discuss how the conformational dynamics of IDPs manifests itself as conformational noise, which can potentially amplify transcriptional noise to stochastically switch cellular phenotypes. Finally, we explore the potential role of IDPs in prebiotic evolution, in forming proteinaceous membrane-less organelles, in the origin of multicellularity, and in protein conformation-based transgenerational inheritance of acquired characteristics. Together, these ideas provide a new conceptual framework to discern how IDPs may perform critical biological functions despite their lack of structure. © 2022 American Chemical Society.

Item Type: Journal Article
Publication: Chemical Reviews
Publisher: American Chemical Society
Additional Information: The copyright for this article belongs to the American Chemical Society.
Keywords: Biology; Computer hardware, Cell fate decision; Cell-be; Cell/B.E; Cell/BE; Complex adaptive systems; Critical component; Hardware and software; Intrinsically disordered proteins; Living cell; Making decision, Proteins
Department/Centre: Division of Biological Sciences > Centre for Neuroscience
Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Division of Physical & Mathematical Sciences > Mathematics
Date Deposited: 18 Mar 2022 11:59
Last Modified: 22 Jun 2022 04:34
URI: https://eprints.iisc.ac.in/id/eprint/71608

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