Aging associated altered response to intracellular bacterial infections and its implication on the host

Fernandes, SE and Alakesh, A and Rajmani, RS and Jhunjhunwala, S and Saini, DK (2021) Aging associated altered response to intracellular bacterial infections and its implication on the host. In: Biochimica et Biophysica Acta - Molecular Cell Research, 1868 (9).

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Abstract

The effects of senescence on geriatric disorders are well explored, but how it influences infections in the elderly is poorly addressed. Here, we show that several anti-microbial responses are elevated in senescent epithelial cells and old mice, which results in decreased bacterial survival in the host after infection. We identify higher levels of iNOS as a crucial host response and show that p38 MAPK in senescent epithelial cells acts as a negative regulator of iNOS transcription. However, in older mice, the ability to impede bacterial infection does not result in enhanced survival, possibly because elevated pro-inflammatory responses are not countered by a robust host protective anti-inflammatory response. Overall, while addressing an alternate advantage of senescent cells, our study demonstrates that infection-associated morbidity in the elderly may not be the sole outcome of pathogen loads but may also be influenced by the host's ability to resolve inflammation-induced damage. © 2021 Elsevier B.V.

Item Type:	Journal Article
Publication:	Biochimica et Biophysica Acta - Molecular Cell Research
Publisher:	Elsevier B.V.
Additional Information:	The copyright for this article belongs to Elsevier B.V.
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics Division of Biological Sciences > Centre for Infectious Disease Research Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	24 Aug 2021 10:24
Last Modified:	24 Aug 2021 10:24
URI:	http://eprints.iisc.ac.in/id/eprint/69304

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