Targeting amino acid metabolism of Mycobacterium tuberculosis for developing inhibitors to curtail its survival

Yelamanchi, SD and Surolia, A (2021) Targeting amino acid metabolism of Mycobacterium tuberculosis for developing inhibitors to curtail its survival. In: IUBMB Life .

PDF iub_lif_2021.pdf - Published Version Restricted to Registered users only Download (2MB) | Request a copy

Abstract

Tuberculosis caused by the bacterium, Mycobacterium tuberculosis (Mtb), continues to remain one of the most devastating infectious diseases afflicting humans. Although there are several drugs for treating tuberculosis available currently, the emergence of the drug resistant forms of this pathogen has made its treatment and eradication a challenging task. While the replication machinery, protein synthesis and cell wall biogenesis of Mtb have been targeted often for anti-tubercular drug development a number of essential metabolic pathways crucial to its survival have received relatively less attention. In this context a number of amino acid biosynthesis pathways have recently been shown to be essential for the survival and pathogenesis of Mtb. Many of these pathways and or their key enzymes homologs are absent in humans hence they could be harnessed for anti-tubercular drug development. In this review, we describe comprehensively the amino acid metabolic pathways essential in Mtb and the key enzymes involved therein that are being investigated for developing inhibitors that compromise the survival and pathogenesis caused by this pathogen. © 2021 International Union of Biochemistry and Molecular Biology.

Item Type:	Journal Article
Publication:	IUBMB Life
Publisher:	Blackwell Publishing Ltd
Additional Information:	The copyright for this article belongs to Blackwell Publishing Ltd
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	23 Mar 2021 10:06
Last Modified:	23 Mar 2021 10:06
URI:	http://eprints.iisc.ac.in/id/eprint/68534

Actions (login required)

View Item