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Microneedles for Extended Transdermal Therapeutics: A Route to Advanced Healthcare

Pahal, S and Badnikar, K and Ghate, V and Bhutani, U and Nayak, MM and Subramanyam, DN and Vemula, PK (2021) Microneedles for Extended Transdermal Therapeutics: A Route to Advanced Healthcare. In: European Journal of Pharmaceutics and Biopharmaceutics, 159 . pp. 151-169.

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Official URL: https://doi.org/10.1016/j.ejpb.2020.12.020


Sustained release of drugs over a pre-determined period is required to maintain an effective therapeutic dose for variety of drug delivery applications. Transdermal devices such as polymeric microneedle patches and other microneedle-based devices have been utilized for sustained release of their payload. Swift clearing of drugs can be prevented either by designing a slow-degrading polymeric matrix or by providing physiochemical triggers to different microneedle-based devices for on-demand release. These long-acting transdermal devices prevent the burst release of drugs. This review highlights the recent advances of microneedle-based devices for sustained release of vaccines, hormones, and antiretrovirals with their prospective safe clinical translation. © 2020 Elsevier B.V.

Item Type: Journal Article
Publication: European Journal of Pharmaceutics and Biopharmaceutics
Publisher: Elsevier B.V.
Additional Information: The copyright for this article belongs to Elsevier B.V.
Department/Centre: Division of Electrical Sciences > Electronic Systems Engineering (Formerly Centre for Electronic Design & Technology)
Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering
Date Deposited: 31 Dec 2021 06:07
Last Modified: 31 Dec 2021 06:07
URI: http://eprints.iisc.ac.in/id/eprint/67796

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