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Signatures of conserved and unique molecular features in Afrotheria

Yazhini, A and Srinivasan, N and Sandhya, S (2021) Signatures of conserved and unique molecular features in Afrotheria. In: Scientific Reports, 11 (1).

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Official URL: https://dx.doi.org/10.1038/s41598-020-79559-6


Afrotheria is a clade of African-origin species with striking dissimilarities in appearance and habitat. In this study, we compared whole proteome sequences of six Afrotherian species to obtain a broad viewpoint of their underlying molecular make-up, to recognize potentially unique proteomic signatures. We find that 62 of the proteomes studied here, predominantly involved in metabolism, are orthologous, while the number of homologous proteins between individual species is as high as 99.5. Further, we find that among Afrotheria, L. africana has several orphan proteins with 112 proteins showing < 30 sequence identity with their homologues. Rigorous sequence searches and complementary approaches were employed to annotate 156 uncharacterized protein sequences and 28 species-specific proteins. For 122 proteins we predicted potential functional roles, 43 of which we associated with protein- and nucleic-acid binding roles. Further, we analysed domain content and variations in their combinations within Afrotheria and identified 141 unique functional domain architectures, highlighting proteins with potential for specialized functions. Finally, we discuss the potential relevance of highly represented protein families such as MAGE-B2, olfactory receptor and ribosomal proteins in L. africana and E. edwardii, respectively. Taken together, our study reports the first comparative study of the Afrotherian proteomes and highlights salient molecular features. © 2021, The Author(s).

Item Type: Journal Article
Publication: Scientific Reports
Publisher: Nature Research
Additional Information: The copyright of this article belongs to Nature Research
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 28 Jan 2021 06:00
Last Modified: 28 Jan 2021 06:00
URI: http://eprints.iisc.ac.in/id/eprint/67780

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