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OVOL1/2: Drivers of Epithelial Differentiation in Development, Disease, and Reprogramming

Saxena, K and Srikrishnan, S and Celia-Terrassa, T and Jolly, MK (2022) OVOL1/2: Drivers of Epithelial Differentiation in Development, Disease, and Reprogramming. In: Cells Tissues Organs, 211 (2). 183 -192.

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Official URL: https://dx.doi.org/10.1159/000511383


OVOL proteins (OVOL1 and OVOL2), vertebrate homologs of Drosophila OVO, are critical regulators of epithelial lineage determination and differentiation during embryonic development in tissues such as kidney, skin, mammary epithelia, and testis. OVOL can inhibit epithelial-mesenchymal transition and/or can promote mesenchymal-epithelial transition. Moreover, they can regulate the stemness of cancer cells, thus playing an important role during cancer cell metastasis. Due to their central role in differentiation and maintenance of epithelial lineage, OVOL overexpression has been shown to be capable of reprogramming fibroblasts to epithelial cells. Here, we review the roles of OVOL-mediated epithelial differentiation across multiple contexts, including embryonic development, cancer progression, and cellular reprogramming.

Item Type: Journal Article
Publication: Cells Tissues Organs
Publisher: S. Karger AG
Additional Information: Copyright of this article belongs to the Authors.
Keywords: OVOL1O, VOL2, Epithelial-mesenchymal transition, Mesenchymal-epithelial, transitionEpithelial differentiation
Department/Centre: Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 15 Oct 2020 07:16
Last Modified: 30 Jun 2022 05:00
URI: https://eprints.iisc.ac.in/id/eprint/66858

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