Weinberg, A and Tugizov, S and Pandiyan, P and Jin, G and Rakshit, S and Vyakarnam, A and Naglik, JR (2020) Innate immune mechanisms to oral pathogens in oral mucosa of HIV-infected individuals. In: Oral Diseases, 26 (S1). pp. 69-79.
|
PDF
ora_dis_26-01_69-79_2020.pdf - Published Supplemental Material Download (727kB) | Preview |
Abstract
A crucial aspect of mucosal HIV transmission is the interaction between HIV, the local environmental milieu and immune cells. The oral mucosa comprises many host cell types including epithelial cells, CD4 + T cells, dendritic cells and monocytes/macrophages, as well as a diverse microbiome predominantly comprising bacterial species. While the oral epithelium is one of the first sites exposed to HIV through oral-genital contact and nursing infants, it is largely thought to be resistant to HIV transmission via mechanisms that are still unclear. HIV-1 infection is also associated with predisposition to secondary infections, such as tuberculosis, and other diseases including cancer. This review addresses the following questions that were discussed at the 8th World Workshop on Oral Health and Disease in AIDS held in Bali, Indonesia, 13 September �15 September 2019: (a) How does HIV infection affect epithelial cell signalling? (b) How does HIV infection affect the production of cytokines and other innate antimicrobial factors, (c) How is the mucosal distribution and function of immune cells altered in HIV infection? (d) How do T cells affect HIV (oral) pathogenesis and cancer? (e) How does HIV infection lead to susceptibility to TB infections?.
| Item Type: | Journal Article |
|---|---|
| Publication: | Oral Diseases |
| Publisher: | Blackwell Publishing Ltd |
| Additional Information: | The copyright of this article belongs to Blackwell Publishing Ltd |
| Department/Centre: | Division of Biological Sciences > Centre for Infectious Disease Research |
| Date Deposited: | 24 Sep 2020 06:22 |
| Last Modified: | 24 Sep 2020 06:22 |
| URI: | http://eprints.iisc.ac.in/id/eprint/66520 |
Actions (login required)
 |
View Item |
