Seifert, Leon Louis and Si, Clara and Saha, Debjani and Sadic, Mohammad and de Vries, Maren and Ballentine, Sarah and Briley, Aaron and Wang, Guojun and Valero-Jimenez, Ana M and Mohamed, Adil and Schaefer, Uwe and Moulton, Hong M and Garcia-Sastre, Adolfo and Tripathi, Shashank and Rosenberg, Brad R and Dittmann, Meike (2019) The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response. In: PLOS PATHOGENS, 15 (11).
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Abstract
Induction of vast transcriptional programs is a central event of innate host responses to viral infections. Here we report a transcriptional program with potent antiviral activity, driven by E74-like ETS transcription factor 1 (ELF1). Using microscopy to quantify viral infection over time, we found that ELF1 inhibits eight diverse RNA and DNA viruses after multi-cycle replication. Elf1 deficiency results in enhanced susceptibility to influenza A virus infections in mice. ELF1 does not feed-forward to induce interferons, and ELF1's antiviral effect is not abolished by the absence of STAT1 or by inhibition of JAK phosphorylation. Accordingly, comparative expression analyses by RNA-seq revealed that the ELF1 transcriptional program is distinct from interferon signatures. Thus, ELF1 provides an additional layer of the innate host response, independent from the action of type I interferons.
| Item Type: | Journal Article |
|---|---|
| Publication: | PLOS PATHOGENS |
| Publisher: | PUBLIC LIBRARY SCIENCE |
| Additional Information: | Copyright of this article belongs to PUBLIC LIBRARY SCIENCE |
| Keywords: | NF-KAPPA-B; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CROHNS-DISEASE; MOLECULAR-MECHANISMS; TARGETED DISRUPTION; STIMULATED GENES; LIGAND-BINDING; ZETA-CHAIN; EXPRESSION; REVEALS |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology Division of Biological Sciences > Centre for Infectious Disease Research |
| Date Deposited: | 10 Jan 2020 08:01 |
| Last Modified: | 10 Jan 2020 08:01 |
| URI: | http://eprints.iisc.ac.in/id/eprint/64307 |
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