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DNA structural features of eukaryotic TATA-containing and TATA-less promoters

Yella, Venkata Rajesh and Bansal, Manju (2017) DNA structural features of eukaryotic TATA-containing and TATA-less promoters. In: FEBS OPEN BIO, 7 (3). pp. 324-334.

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Official URL: http://dx.doi.org/10.1002/2211-5463.12166


Eukaryotic genes can be broadly classified as TATA-containing and TATA-less based on the presence of TATA box in their promoters. Experiments on both classes of genes have revealed a disparity in the regulation of gene expression and cellular functions between the two classes. In this study, we report characteristic differences in promoter sequences and associated structural properties of the two categories of genes in six different eukaryotes. We have analyzed three structural features, DNA duplex stability, bendability, and curvature along with the distribution of A-tracts, G-quadruplex motifs, and CpG islands. The structural feature analyses reveal that while the two classes of gene promoters are distinctly different from each other, the properties are also distinguishable across the six organisms.

Item Type: Journal Article
Publication: FEBS OPEN BIO
Additional Information: Copy right for this article belongs to the WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 25 May 2017 10:08
Last Modified: 25 May 2017 10:08
URI: http://eprints.iisc.ac.in/id/eprint/57069

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