Aberrant lysine acetylation in tumorigenesis: Implications in the development of therapeutics

Kaypee, Stephanie and Sudarshan, Deepthi and Shanmugam, Muthu K and Mukherjee, Debanjan and Sethi, Gautam and Kundu, Tapas K (2016) Aberrant lysine acetylation in tumorigenesis: Implications in the development of therapeutics. In: PHARMACOLOGY & THERAPEUTICS, 162 . pp. 98-119.

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Abstract

The `language' of covalent histone modifications translates environmental and cellular cues into gene expression. This vast array of post-translational modifications on histones are more than just covalent moieties added onto a protein, as they also form a platform on which crucial cellular signals are relayed. The reversible lysine acetylation has emerged as an important post-translational modification of both histone and non-histone proteins, dictating numerous epigenetic programs within a cell. Thus, understanding the complex biology of lysine acetylation and its regulators is essential for the development of epigenetic therapeutics. In this review, we will attempt to address the complexities of lysine acetylation in the context of tumorigenesis, their role in cancer progression and emphasize on the modalities developed to target lysine acetyltransferases towards cancer treatment. (C) 2016 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Publication:	PHARMACOLOGY & THERAPEUTICS
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Additional Information:	Copy right of this article belongs to the PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Department/Centre:	Division of Mechanical Sciences > Mechanical Engineering
Date Deposited:	17 Aug 2016 04:46
Last Modified:	31 Oct 2018 13:58
URI:	http://eprints.iisc.ac.in/id/eprint/54279

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