Ahmed, A and Rakshit, S and Vyakarnam, A (2016) HIV-TB co-infection: mechanisms that drive reactivation of Mycobacterium tuberculosis in HIV infection. In: 7th World Workshop on Oral Health and Disease in AIDS, NOV 06-09, 2014, Hyderabad, INDIA, pp. 53-60.
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Abstract
HIV infection predisposes the host to tuberculosis by impairing the hosts' immune system principally by killing and altering CD4 T-cell function. How HIV infection disrupts CD4 T-cell function, which specifically compromises host immunity to Mycobacterium tuberculosis, is poorly understood and is a critical roadblock in developing better vaccine- or immune-based strategies to control and monitor TB in HIV-infected subjects. This review considers key pathways that are altered in HIV-infected subjects that impair anti-TB immunity.
Item Type: | Conference Proceedings |
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Publication: | ORAL DISEASES |
Publisher: | WILEY-BLACKWELL |
Additional Information: | Copy right for this article belongs to the WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA |
Keywords: | Tuberculosis; HIV; CD4 T cell; Interferon; reactivation |
Department/Centre: | Division of Biological Sciences > Centre for Infectious Disease Research |
Date Deposited: | 15 Jun 2016 05:22 |
Last Modified: | 15 Jun 2016 05:22 |
URI: | http://eprints.iisc.ac.in/id/eprint/53912 |
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