Peptide-utilizing carbon starvation gene yjiY is required for flagella-mediated infection caused by Salmonella

Garai, Preeti and Lahiri, Amit and Ghosh, Dipan and Chatterjee, Jayanta and Chakravortty, Dipshikha (2016) Peptide-utilizing carbon starvation gene yjiY is required for flagella-mediated infection caused by Salmonella. In: MICROBIOLOGY-SGM, 162 (1). pp. 100-116.

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Abstract

Peptide metabolism forms an important part of the metabolic network of Salmonella and to acquire these peptides the pathogen possesses a number of peptide transporters. Whilst various peptide transporters known in Salmonella are well studied, very little is known about the carbon starvation (cst) genes cstA and yjiY, which are also predicted to be involved in peptide metabolism. We investigated the role of these genes in the metabolism and pathogenesis of Salmonella, and demonstrated for the first time, to the best of our knowledge, that cst genes actually participate in transport of specific peptides in Salmonella. Furthermore, we established that the carbon starvation gene yjiY affects the expression of flagella, leading to poor adhesion of the bacterium to host cells. In contrast to the previously reported role of cstA in virulence of Salmonella in Caenorhabditis elegans, we showed that yjiY is required for successful colonization of Salmonella in the mouse gut. Thus, cst genes not only contribute to the metabolism of Salmonella, but also influence its virulence.

Item Type:	Journal Article
Publication:	MICROBIOLOGY-SGM
Publisher:	SOC GENERAL MICROBIOLOGY
Additional Information:	Copy right for this article belongs to the SOC GENERAL MICROBIOLOGY, MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	07 Apr 2016 05:06
Last Modified:	07 Apr 2016 05:06
URI:	http://eprints.iisc.ac.in/id/eprint/53498

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