Novel multimeric IL-1 receptor antagonist for the treatment of rheumatoid arthritis

Pasi, Shweta and Kant, Ravi and Gupta, Sarika and Surolia, Avadhesha (2015) Novel multimeric IL-1 receptor antagonist for the treatment of rheumatoid arthritis. In: BIOMATERIALS, 42 . pp. 121-133.

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Abstract

Protein therapeutics targeting inflammatory mediators have shown great promise for the treatment of autoimmunities such as rheumatoid arthritis (RA). However, a significant challenge in this area has been their low in vivo stability and consequently their severely compromised therapeutic efficacy. One such therapeutic molecule IL-1 receptor antagonist (IL-1ra), used in the treatment of rheumatoid arthritis, has displayed only modest efficacy in human clinical trials owing to its short biological half-life. Herein, we report a novel approach to conglomerate individual protein entities into a drug depot by incorporation of an amyloidogenic motif Lys-Phe-Phe-Glu (KFFE) thereby dramatically improving their systemic persistence and in turn their therapeutic efficacy in a mice model of autoimmune arthritis. (C) 2014 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Publication:	BIOMATERIALS
Publisher:	ELSEVIER SCI LTD
Keywords:	IL-1 receptor antagonist; Multimeric; Rheumatoid arthritis; Anakinra
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	19 Mar 2015 12:06
Last Modified:	19 Mar 2015 12:06
URI:	http://eprints.iisc.ac.in/id/eprint/51037

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