Lal, Girdhari and Shaila, MS and Nayak, Rabindranath (2006) Idiotypic T cells specific for Morbillivirus nucleocapsid protein process and present their TCR to cognate anti-idiotypic $CD8^+ T$ cells. In: Immunology Letters, 102 (2). pp. 132-140.
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Abstract
$CD8^+ T$ cells are activated by the presentation of antigenic peptide through MHC class I molecules. Newly synthesized proteins formed as defective ribosomal products (DRiPs) can act as a major source of antigenic peptides for MHC class I presentation pathway. Majority of these peptides are generated from the intracellular degradation of self antigens. In the present study, we have shown that newly synthesized T cell receptor (TCR) beta chains formed as DRiPs in T cells are ubiquitinated and degraded by the proteasomes. These TCR-DRiPs are processed and presented by activated T cells to cognate anti-idiotypic $CD8^+ T$ cells. Presentation of TCR idiopeptide (peptide derived from the variable region of idiotypic TCR) by activated T cells leads to Bcl-2 expression and cytokine secretion by anti-idiotypic $CD8^+ T$ cells. Presentation of intracellular antigen by T cells may have important implications in immunoregulation, control of lymphotropic virus infection and autoimmune diseases.
Item Type: | Journal Article |
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Publication: | Immunology Letters |
Publisher: | Elsevier BV |
Additional Information: | The Copyright belongs to Elsevier BV. |
Keywords: | T-APC;Proteasome;DRiPs;Anti-idiotypic T cells |
Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology |
Date Deposited: | 20 Jan 2006 |
Last Modified: | 19 Sep 2010 04:22 |
URI: | http://eprints.iisc.ac.in/id/eprint/5089 |
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