Idiotypic T cells specific for Morbillivirus nucleocapsid protein process and present their TCR to cognate anti-idiotypic $CD8^+ T$ cells

Lal, Girdhari and Shaila, MS and Nayak, Rabindranath (2006) Idiotypic T cells specific for Morbillivirus nucleocapsid protein process and present their TCR to cognate anti-idiotypic $CD8^+ T$ cells. In: Immunology Letters, 102 (2). pp. 132-140.

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Abstract

$CD8^+ T$ cells are activated by the presentation of antigenic peptide through MHC class I molecules. Newly synthesized proteins formed as defective ribosomal products (DRiPs) can act as a major source of antigenic peptides for MHC class I presentation pathway. Majority of these peptides are generated from the intracellular degradation of self antigens. In the present study, we have shown that newly synthesized T cell receptor (TCR) beta chains formed as DRiPs in T cells are ubiquitinated and degraded by the proteasomes. These TCR-DRiPs are processed and presented by activated T cells to cognate anti-idiotypic $CD8^+ T$ cells. Presentation of TCR idiopeptide (peptide derived from the variable region of idiotypic TCR) by activated T cells leads to Bcl-2 expression and cytokine secretion by anti-idiotypic $CD8^+ T$ cells. Presentation of intracellular antigen by T cells may have important implications in immunoregulation, control of lymphotropic virus infection and autoimmune diseases.

Item Type:	Journal Article
Publication:	Immunology Letters
Publisher:	Elsevier BV
Additional Information:	The Copyright belongs to Elsevier BV.
Keywords:	T-APC;Proteasome;DRiPs;Anti-idiotypic T cells
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	20 Jan 2006
Last Modified:	19 Sep 2010 04:22
URI:	http://eprints.iisc.ac.in/id/eprint/5089

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