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Structural diversity and ligand specificity of lectins. The Bangalore effort

Abhinav, KV and Vijayan, Mamannamana (2014) Structural diversity and ligand specificity of lectins. The Bangalore effort. In: PURE AND APPLIED CHEMISTRY, 86 (9). pp. 1335-1355.

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Official URL: http://dx.doi.org/ 10.1515/pac-2014-0607


Structural studies in this laboratory encompass four of the five major classes of plant lectins, including the one discovered by us. In addition to addressing issues specific to individual lectins, the work provided insights into protein folding, quaternary association and generation of ligand specificity. Legume and beta-prism fold lectins constitute families of proteins in which small alterations in essentially the same tertiary structure lead to large variations in quaternary structure, including that involving an open structure. Strategies for generating ligand specificity include water bridges, variation in loop length, post translational modification and oligomerization. Three of the structural classes investigated have subunits with three-fold symmetry. The symmetry in the structure is reflected in the sequence to different extents in different subclasses. The evolutionary implications of this observation have been explored. The work on lectins has now been extended to those from mycobacteria.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the WALTER DE GRUYTER GMBH, GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
Keywords: lectin folds; ligand specificity; ICS-27; molecular evolution; mycobacterial lectins; quaternary association
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 29 Dec 2014 05:13
Last Modified: 22 Feb 2019 05:47
URI: http://eprints.iisc.ac.in/id/eprint/50542

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