C-11/C-9 Helices in Crystals of alpha beta Hybrid Peptides and Switching Structures between Helix Types by Variation in the alpha-Residue

Basuroy, Krishnayan and Karuppiah, Vasantham and Balaram, Padmanabhan (2014) C-11/C-9 Helices in Crystals of alpha beta Hybrid Peptides and Switching Structures between Helix Types by Variation in the alpha-Residue. In: ORGANIC LETTERS, 16 (17). pp. 4614-4617.

PDF org_let_16-17_4614_2014.pdf - Published Version Restricted to Registered users only Download (1MB) | Request a copy

Abstract

Close-packed helices with mixed hydrogen bond directionality are unprecedented in the structural chemistry of alpha-polypeptides. While NMR studies in solution state provide strong evidence for the occurrence of mixed helices in (beta beta)(n) and (alpha beta)(n) sequences, limited information is currently available in crystals. The peptide structures presented show the occurrence of C-11/C-9 helices in (alpha beta)(n) peptides. Transitions between C-11 and C-11/C-9 helices are observed upon varying the alpha-amino acid residue.

Item Type:	Journal Article
Publication:	ORGANIC LETTERS
Publisher:	AMER CHEMICAL SOC,
Additional Information:	Copy right for this article belongs to the AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	18 Oct 2014 06:36
Last Modified:	18 Oct 2014 06:36
URI:	http://eprints.iisc.ac.in/id/eprint/50018

Actions (login required)

View Item