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Role of DNA sequence based structural features of promoters in transcription initiation and gene expression

Bansal, Manju and Kumar, Aditya and Yella, Venkata Rajesh (2014) Role of DNA sequence based structural features of promoters in transcription initiation and gene expression. In: CURRENT OPINION IN STRUCTURAL BIOLOGY, 25 . pp. 77-85.

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Official URL: http://dx.doi.org/ 10.1016/j.sbi.2014.01.007


D Regulatory information for transcription initiation is present in a stretch of genomic DNA, called the promoter region that is located upstream of the transcription start site (TSS) of the gene. The promoter region interacts with different transcription factors and RNA polymerase to initiate transcription and contains short stretches of transcription factor binding sites (TFBSs), as well as structurally unique elements. Recent experimental and computational analyses of promoter sequences show that they often have non-B-DNA structural motifs, as well as some conserved structural properties, such as stability, bendability, nucleosome positioning preference and curvature, across a class of organisms. Here, we briefly describe these structural features, the differences observed in various organisms and their possible role in regulation of gene expression.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 19 Aug 2014 09:10
Last Modified: 19 Aug 2014 09:10
URI: http://eprints.iisc.ac.in/id/eprint/49565

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