Balakrishnan, Arjun and Marathe, Sandhya A and Joglekar, Madhura and Chakravortty, Dipshikha (2013) Bactericidal/permeability increasing protein: A multifaceted protein with functions beyond LPS neutralization. In: INNATE IMMUNITY, 19 (4). pp. 339-347.
Full text not available from this repository. (Request a copy)Abstract
Bactericidal permeability increasing protein (BPI), a 55-60kDa protein, first reported in 1975, has gone a long way as a protein with multifunctional roles. Its classical role in neutralizing endotoxin (LPS) raised high hopes among septic shock patients. Today, BPI is not just a LPS-neutralizing protein, but a protein with diverse functions. These functions can be as varied as inhibition of endothelial cell growth and inhibition of dendritic cell maturation, or as an anti-angiogenic, chemoattractant or opsonization agent. Though the literature available is extremely limited, it is fascinating to look into how BPI is gaining major importance as a signalling molecule. In this review, we briefly summarize the recent research focused on the multiple roles of BPI and its use as a therapeutic.
| Item Type: | Journal Article |
|---|---|
| Publication: | INNATE IMMUNITY |
| Publisher: | SAGE PUBLICATIONS LTD |
| Additional Information: | Copyright of this article is belongs to SAGE PUBLICATIONS |
| Keywords: | Bactericidal; permeability increasing protein (BPI); antimicrobial peptides; PLUNC proteins; endotoxic shock; Gram-negative bacteria |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology Division of Biological Sciences > Centre for Infectious Disease Research |
| Date Deposited: | 03 Sep 2013 08:50 |
| Last Modified: | 03 Sep 2013 11:37 |
| URI: | http://eprints.iisc.ac.in/id/eprint/47030 |
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