Mukherjee, Sumanta and Sambarey, Awanti and Prashanthi, Karyala and Chandra, Nagasuma (2013) Current trends in modeling hostpathogen interactions. In: WILEY INTERDISCIPLINARY REVIEWS-DATA MINING AND KNOWLEDGE DISCOVERY, 3 (2). pp. 109-128.
Full text not available from this repository. (Request a copy)Abstract
The rapid emergence of infectious diseases calls for immediate attention to determine practical solutions for intervention strategies. To this end, it becomes necessary to obtain a holistic view of the complex hostpathogen interactome. Advances in omics and related technology have resulted in massive generation of data for the interacting systems at unprecedented levels of detail. Systems-level studies with the aid of mathematical tools contribute to a deeper understanding of biological systems, where intuitive reasoning alone does not suffice. In this review, we discuss different aspects of hostpathogen interactions (HPIs) and the available data resources and tools used to study them. We discuss in detail models of HPIs at various levels of abstraction, along with their applications and limitations. We also enlist a few case studies, which incorporate different modeling approaches, providing significant insights into disease. (c) 2013 Wiley Periodicals, Inc.
| Item Type: | Journal Article |
|---|---|
| Publication: | WILEY INTERDISCIPLINARY REVIEWS-DATA MINING AND KNOWLEDGE DISCOVERY |
| Publisher: | WILEY PERIODICALS, INC |
| Additional Information: | Copyright for this article belongs to WILEY PERIODICALS, SAN FRANCISCO, USA |
| Department/Centre: | Division of Biological Sciences > Biochemistry Division of Biological Sciences > Molecular Biophysics Unit Division of Physical & Mathematical Sciences > Mathematics |
| Date Deposited: | 28 Mar 2013 11:53 |
| Last Modified: | 28 Mar 2013 11:53 |
| URI: | http://eprints.iisc.ac.in/id/eprint/46245 |
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