Theoretical Studies on Peptidoglycans. I. Effect of L-Alanyl, D-Butyl, or D-Valyl Residues at the Positions 4 or 5 of the Pentapeptide Moiety of Peptidoglycan on the Cross-Linking Reaction

Virudachalam, R and Rao, VSR (1978) Theoretical Studies on Peptidoglycans. I. Effect of L-Alanyl, D-Butyl, or D-Valyl Residues at the Positions 4 or 5 of the Pentapeptide Moiety of Peptidoglycan on the Cross-Linking Reaction. In: Biopolymers, 17 (9). pp. 2251-2263.

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Abstract

Possible conformations of $X-D-alany^{l4}-D-alanine^5$ and its analogs $X-L-analy^{l4}-D-alanine^5 X-D-alany^{l4}-L-alanine^5, X-D-buty^{l4}-D-alanine^5, X-D-alany^{l4}-D-butyric acid^5, X-D-valy^{l4}-D-alanine^5, and X-D-alany^{l4}-D-valine^5$ have been analyzed by theoretical methods. These studies suggest that L-alanine and D-valine at the 4 or 5 postion of the pentapeptide moiety of peptidoglycan will drastically reduce the cross-linking in peptidoglycan biosynthesis, whereas the effect of D- butyric acid will be marked at the 4 postition and modeate at the 5 position. This is in good agreement with experimental results. The cross-linking enzyme transpeptidase requires a specific confroamation for the 4th and 5th residues for optimal binding.

Item Type:	Journal Article
Publication:	Biopolymers
Publisher:	John Wiley & Sons, Inc.
Additional Information:	The copyright belongs to John Wiley & Sons, Inc.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	07 Dec 2005
Last Modified:	19 Sep 2010 04:21
URI:	http://eprints.iisc.ac.in/id/eprint/4289

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