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Structural biology of Mycobacterium tuberculosis proteins: The Indian efforts

Arora, Ashish and Chandra, Nagasuma R and Das, Amit and Gopal, Balasubramanian and Mande, Shekhar C and Prakash, Balaji and Ramachandran, Ravishankar and Sankaranarayanan, Rajan and Sekar, K and Suguna, Kaza and Tyagi, Anil K and Vijayan, Mamannamana (2011) Structural biology of Mycobacterium tuberculosis proteins: The Indian efforts. In: Tuberculosis, 91 (5, SI). pp. 456-468.

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Official URL: http://dx.doi.org/10.1016/j.tube.2011.03.004


Among the many different objectives of large scale structural genomics projects are expanding the protein fold space, enhancing understanding of a model or disease-related organism, and providing foundations for structure-based drug discovery. Systematic analysis of protein structures of Mycobacterium tuberculosis has been ongoing towards meeting some of these objectives. Indian participation in these efforts has been enthusiastic and substantial. The proteins of M. tuberculosis chosen for structural analysis by the Indian groups span almost all the functional categories. The structures determined by the Indian groups have led to significant improvement in the biochemical knowledge on these proteins and consequently have started providing useful insights into the biology of M. tuberculosis. Moreover, these structures form starting points for inhibitor design studies, early results of which are encouraging. The progress made by Indian structural biologists in determining structures of M. tuberculosis proteins is highlighted in this review. (C) 2011 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Publication: Tuberculosis
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Structural genomics;X-ray crystallography;NMR;Inhibitor design
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Division of Information Sciences (Doesn't exist now) > BioInformatics Centre
Date Deposited: 04 Nov 2011 05:10
Last Modified: 04 Nov 2011 05:10
URI: http://eprints.iisc.ac.in/id/eprint/41655

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