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Enantioselective total synthesis of macrosphelides A and E

Prasad, Kavirayani R and Gutala, Phaneendra (2011) Enantioselective total synthesis of macrosphelides A and E. In: Tetrahedron, 67 (25). pp. 4514-4520.

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Official URL: http://dx.doi.org/10.1016/j.tet.2011.04.099


Enantioselective synthesis of 16-membered trilactone macrolides, macrosphelide A and E from (S)-lactic acid is described. Key features of the synthesis include the utility of a hitherto unexplored beta-ketophosphonate derived from lactic acid and Yamaguchi lactonization leading to the title compounds. (C) 2011 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Publication: Tetrahedron
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Total synthesis;Macrolactone;Lactic acid;Macrosphelides
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 05 Jul 2011 10:11
Last Modified: 05 Jul 2011 10:11
URI: http://eprints.iisc.ac.in/id/eprint/38868

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