NMR Assignment of the Holo-ACP from Malaria Parasite Plasmodium falciparum

Sharma, Alok Kumar and Sharma, Shailendra Kumar and Surolia, Namita and Sarma, Siddhartha P (2005) NMR Assignment of the Holo-ACP from Malaria Parasite Plasmodium falciparum. In: Journal of Biomolecular NMR, 32 (3). p. 260.

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Abstract

Malaria remains one of the leading global diseases in terms of both morbidity and mortality with about 2 million deaths occurring annually (WHO repor t, 2002). Out of the four species of Plasmodium that infect human, the infection caused by Plasmodium falciparum is most fatal. The resistance of Plasmodium falciparum to currently used drugs has resulted in a resurgence of malaria. The need for new drugs targets and drugs is thus imperative. The primary metabolic pathways that occur in the parasite offer an attractive target for the development of new drugs. One such metabolic pathway is the fatty acid biosynthesis pathway (FAB pathway), which is of the type II in the parasite as opposed to the type I pathway that is present in the host (mammals)(Wiesner and Seeber, 2005).

Item Type:	Journal Article
Publication:	Journal of Biomolecular NMR
Publisher:	Springer
Additional Information:	Copyright for this article belongs to Springer.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	27 Sep 2005
Last Modified:	19 Sep 2010 04:20
URI:	http://eprints.iisc.ac.in/id/eprint/3730

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