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Genome analysis: A new approach for visualization of sequence organization in genomes

Pradeep Kumar, Burma and Alok, Raj and SK, Brahmachari and Jayant, Deb K (1992) Genome analysis: A new approach for visualization of sequence organization in genomes. In: Journal of Biosciences, 17 (4). pp. 395-411.

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In this article we describe and demonstrate the versatility of a computer program, GENOME MAPPING, that uses interactive graphics and runs on an IRIS workstation. The program helps to visualize as well as analyse global and local patterns of genomic DNA sequences. It was developed keeping in mind the requirements of the human genome sequencing programme, which requires rapid analysis of the data. Using GENOME MAPPING one can discern signature patterns of different kinds of sequences and analyse such patterns for repetitive as well as rare sequence strings. Further, one can visualize the extent of global homology between different genomic sequences. An application of our method to the published yeast mitochondrial genome data shows similar sequence organizations in the entire sequence and in smaller subsequences.

Item Type: Journal Article
Publication: Journal of Biosciences
Publisher: Indian Academy of Sciences
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Keywords: Genome mapping;DNA sequence analysis;fractal;chaos game representation;mitochondrial genomes;Mycobacterium; nucleotide sequences.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 02 Apr 2011 04:51
Last Modified: 02 Apr 2011 04:51
URI: http://eprints.iisc.ac.in/id/eprint/36141

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