Surolia, Namita and Padmanaban, Govindarajan (1992) devovo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite. In: Biochemical and Biophysical Research Communications, 187 (2). pp. 744-750.
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Official URL: http://dx.doi.org/10.1016/0006-291X(92)91258-R
Abstract
The human malarial parasite, Image , has been found to synthesize heme Image , despite the accumulation of large quantities of polymeric heme derived from the hemoglobin of the red cell host. The parasite δ-aminolevulinate dehydrase level is significantly lower than that of the host and its inhibition by succinylacetone leads to inhibition of parasite protein synthesis and viability.
| Item Type: | Journal Article |
|---|---|
| Publication: | Biochemical and Biophysical Research Communications |
| Publisher: | Elsevier science |
| Additional Information: | Copyright of this article belongs to Elsevier science. |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 25 Jan 2011 04:58 |
| Last Modified: | 23 Oct 2018 11:04 |
| URI: | http://eprints.iisc.ac.in/id/eprint/35162 |
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