devovo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite

Surolia, Namita and Padmanaban, Govindarajan (1992) devovo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite. In: Biochemical and Biophysical Research Communications, 187 (2). pp. 744-750.

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Abstract

The human malarial parasite, Image , has been found to synthesize heme Image , despite the accumulation of large quantities of polymeric heme derived from the hemoglobin of the red cell host. The parasite δ-aminolevulinate dehydrase level is significantly lower than that of the host and its inhibition by succinylacetone leads to inhibition of parasite protein synthesis and viability.

Item Type:	Journal Article
Publication:	Biochemical and Biophysical Research Communications
Publisher:	Elsevier science
Additional Information:	Copyright of this article belongs to Elsevier science.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	25 Jan 2011 04:58
Last Modified:	23 Oct 2018 11:04
URI:	http://eprints.iisc.ac.in/id/eprint/35162

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