Polypeptide models of collagen. II. Solution properties of (Pro-Gly-Phe)n

Brahmachari, Samir K and Ananthanarayanan, VS and Rapaka, Rao S and Bhatnagar, Rajendra S (1978) Polypeptide models of collagen. II. Solution properties of (Pro-Gly-Phe)n. In: Biopolymers, 17 (9). 2097-2105 .

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Abstract

The conformation of (Pro-Gly-Phe)n in trifluoroethanol was investigated using CD, nmr and ir techniques. After making appropriate correction for the contribution of the phenylalanine chromophore to the observed CD spectra of the polytripeptide at several temperatures, it is found that (Pro-Gly-Phe)n can exist in a partially triple-helical conformation in this solvent a t low temperatures. The nmr and ir data support this conclusion. In conjunction with recent theoretical sutdies, our data offer an explanation for the preferential occurrence of the Phe residue in position 2 of the tripeptide sequence Gly-R2-R3, in collagen.

Item Type:	Journal Article
Publication:	Biopolymers
Publisher:	John Wiley & Sons
Additional Information:	Copyright of this article belongs to John Wiley & Sons.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	29 Sep 2010 11:24
Last Modified:	29 Sep 2010 11:24
URI:	http://eprints.iisc.ac.in/id/eprint/32517

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