Interruptions of (CG)n sequences by GG, TG and CA need not prevent B to Z transition in solution

Mishra, Rakesh K and Latha, PK and Brahmachari, Samir K (1988) Interruptions of (CG)n sequences by GG, TG and CA need not prevent B to Z transition in solution. In: Nucleic Acids Research, 16 (10). pp. 4651-4665.

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Abstract

Oligonucleotides containing alternating purines-pyrimidines with AT base pairs have been shown to exist in the Z-form preferably in solid state. We report that oligodeoxyribonucleotides with GG, TG and CA interruptions in their alternating CG sequences can undergo B to Z transition in solution in the absence of any chemical modification or topological constraint. The sequences, d(CGCGCGGCGCGC) and d(CGTGCGCACG) have been synthesised and shown to adopt Z- conformation in presence of millimolar concentrations of Ni2+ under low water activity conditions. Significance of GG, TG and CA interruptions in the B to Z transition is discussed.

Item Type:	Journal Article
Publication:	Nucleic Acids Research
Publisher:	Oxford University Press
Additional Information:	Copyright of this article belongs to Oxford University Press.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	19 Nov 2010 06:07
Last Modified:	19 Nov 2010 06:07
URI:	http://eprints.iisc.ac.in/id/eprint/32334

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