Molecular Structure of t-Butyloxycarbonyl-Leu-Aib-Pro-Val-Aib-Methyl Ester, a Fragment of Alamethicin and Suzukacillin: A $3_{10}$-Helical Pentapeptide

Rao, Pulla and Balaram, P (1982) Molecular Structure of t-Butyloxycarbonyl-Leu-Aib-Pro-Val-Aib-Methyl Ester, a Fragment of Alamethicin and Suzukacillin: A $3_{10}$-Helical Pentapeptide. In: Biopolymers, 21 (12). pp. 2461-2472.

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Abstract

The pentapeptide Boc-Leu-Aib-Pro-Val-Aib-OMe, a fragment of alamethicin and suzukacillin, crystallizes in the space group ${P2}_1$, with a = 11.034 (2), b = 10.894 (2) , c = 15.483 (2) A, \beta = 104.80 (2) deg and Z = 2. The crystal structure has been solved by direct methods and refined to an R value of 0.069. The peptide backbone folds into a right-handed $3_{10}$-helical conformation, stabilized by two intramolecular 4 \rightarrow 1 hydrogen bonds between the Leu(1) CO and Val(4) NH and Aib(2) CO and Aib(5) NH groups. The solid-state conformation is consistent with results of spectroscopic analysis in solution.

Item Type:	Journal Article
Publication:	Biopolymers
Publisher:	John Wiley & Sons, Inc
Additional Information:	Copyright for this article belongs to John Wiley & Sons, Inc.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	16 Mar 2005
Last Modified:	19 Sep 2010 04:18
URI:	http://eprints.iisc.ac.in/id/eprint/2907

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