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Asymmetric total synthesis of erythromycin. 3. Total synthesis of erythromycin

Woodward, RB and Logusch, E and Nambiar, KP and Sakan, K and Ward, DE and Au-Yeung, BW and Balaram, Padmanabhan (1981) Asymmetric total synthesis of erythromycin. 3. Total synthesis of erythromycin. In: Journal of the American Chemical Society, 103 (11). 3215 -3217.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/ja00401a051?pr...


In the preceding paper' we described the preparation of the key lactone intermediate la in optically active form. In this paper we report the synthesis of erythromycin (2) from la. In essence,this transformation involves the glycosidation of a suitable derivative of la with L-cladinose and D-desosamine and the generation of the C-9 ketone functionality.

Item Type: Editorials/Short Communications
Publication: Journal of the American Chemical Society
Publisher: American Chemical Society
Additional Information: Copyright of this article belongs to American Chemical Society.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 19 Feb 2010 08:56
Last Modified: 19 Sep 2010 05:55
URI: http://eprints.iisc.ac.in/id/eprint/25681

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