Woodward, RB and Logusch, E and Nambiar, KP and Sakan, K and Ward, DE and Au-Yeung, BW and Balaram, Padmanabhan (1981) Asymmetric total synthesis of erythromycin. 3. Total synthesis of erythromycin. In: Journal of the American Chemical Society, 103 (11). 3215 -3217.
PDF
62.pdf - Published Version Restricted to Registered users only Download (465kB) | Request a copy |
Official URL: http://pubs.acs.org/doi/abs/10.1021/ja00401a051?pr...
Abstract
In the preceding paper' we described the preparation of the key lactone intermediate la in optically active form. In this paper we report the synthesis of erythromycin (2) from la. In essence,this transformation involves the glycosidation of a suitable derivative of la with L-cladinose and D-desosamine and the generation of the C-9 ketone functionality.
Item Type: | Editorials/Short Communications |
---|---|
Publication: | Journal of the American Chemical Society |
Publisher: | American Chemical Society |
Additional Information: | Copyright of this article belongs to American Chemical Society. |
Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit |
Date Deposited: | 19 Feb 2010 08:56 |
Last Modified: | 19 Sep 2010 05:55 |
URI: | http://eprints.iisc.ac.in/id/eprint/25681 |
Actions (login required)
View Item |