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Conformational studies on cyclic dipeptides

Ramani, R and Sasisekharan, V and Venkatesan, K (1977) Conformational studies on cyclic dipeptides. In: International Journal of Peptide and Protein Research, 9 (4). pp. 277-292.

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Official URL: http://www3.interscience.wiley.com/journal/1215309...


An analysis of 11 crystal structures of cyclic dipeptides so far reported in the literature is made, with main reference to the internal parameters of these molecules. Preferred conformations of the side chains of cyclic dipeptides with different α-amino acid residues have been studied by classical energy calculations. The possible conformations of the DKP ring are also studied. The significance of the non-bonded interaction in deciding the pathway for conformational change has also been investigated. The agreement between theoretical results and experimental observations is quite good, both with respect to the conformation of these molecules as well as the enthalpy difference as estimated from n.m.r. studies between different conformers.

Item Type: Journal Article
Publication: International Journal of Peptide and Protein Research
Publisher: Wiley Interscience
Additional Information: Copyright of this article belongs to Wiley Interscience.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Division of Chemical Sciences > Organic Chemistry
Date Deposited: 02 Feb 2010 07:53
Last Modified: 02 Feb 2010 07:53
URI: http://eprints.iisc.ac.in/id/eprint/24589

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