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Understanding Protein Structure from a Percolation Perspective

Deb, Dhruba and Vishveshwara, Saraswathi and Vishveshwara, Smitha (2009) Understanding Protein Structure from a Percolation Perspective. In: Biophysical Journal, 97 (6). pp. 1787-1794.

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Underlying the unique structures and diverse functions of proteins area vast range of amino-acid sequences and a highly limited number of folds taken up by the polypeptide backbone. By investigating the role of noncovalent connections at the backbone level and at the detailed side-chain level, we show that these unique structures emerge from interplay between random and selected features. Primarily, the protein structure network formed by these connections shows simple (bond) and higher order (clique) percolation behavior distinctly reminiscent of random network models. However, the clique percolation specific to the side-chain interaction network bears signatures unique to proteins characterized by a larger degree of connectivity than in random networks. These studies reflect some salient features of the manner in which amino acid sequences select the unique structure of proteins from the pool of a limited number of available folds.

Item Type: Journal Article
Publication: Biophysical Journal
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier science.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 29 Dec 2009 11:02
Last Modified: 19 Sep 2010 05:50
URI: http://eprints.iisc.ac.in/id/eprint/24555

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