Conformational studies of phynyl and isoxazolyl penicillins

Vasudevan, TK and Rao, VSR (1982) Conformational studies of phynyl and isoxazolyl penicillins. In: Current Science, 51 (8). pp. 402-406.

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Abstract

Conformational energy calculations have been carried out on a few representative b-lactamase resistant and susceptible, phenyl and isoxazolyl penicillins. These studies, in agreement with those of earlier workers, show that the 6b-side chains of resistants penicillins are highly rigid as compared to those of susceptible penicillins. The present studies also suggest that the degree of resistant to b-lactamases depends not only on the rigidity of the side chain but also on the nature and orientation of the substituent, beyond the amide carbonyl group in the side chain. The overall shapes of these penicillins correlate well with their antibacterial properties.

Item Type:	Journal Article
Publication:	Current Science
Publisher:	Indian Academy of Sciences
Additional Information:	Copyright of this article belongs to Indian Academy of Sciences.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	23 Dec 2009 05:49
Last Modified:	19 Sep 2010 05:44
URI:	http://eprints.iisc.ac.in/id/eprint/23102

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