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Conformations of lasalocid A-lithium complexes in acetonitrile

Shastri, BP and Easwaran, KRK (1984) Conformations of lasalocid A-lithium complexes in acetonitrile. In: International Journal of Biological Macromolecules, 6 (4). pp. 219-223.

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The interaction of the ionophore antibiotic lasalocid-A with lithium perchlorate in acetonitrile has been studied by circular dichroism (c.d.) and 1H, 13C and 7Li nuclear magnetic resonance (n.m.r.) techniques. Analysis of the c.d. data has shown that both the 2:1 sandwich (ionophore-cation-ionosphore) complex and 1:1 complex coexist in solution. The n.m.r. data are consistent with a conformational model in which the carbonyl oxygen, he tetrahydrofuran and the tetrahydropyran ring oxygen atoms, two hydroxyl group oxygens and either a water or a solvent molecule coordinate to the lithium ion.

Item Type: Journal Article
Publication: International Journal of Biological Macromolecules
Publisher: Elsevier Science
Additional Information: Copyright for this article belongs to Elsevier Science.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 18 Aug 2009 05:13
Last Modified: 19 Sep 2010 05:41
URI: http://eprints.iisc.ac.in/id/eprint/22347

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