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Theoretical studies on the conformations of higher gangliosides

Veluraja, K and Rao, VSR (1984) Theoretical studies on the conformations of higher gangliosides. In: Carbohydrate Polymers, 4 ( 5). pp. 357-375.

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The possible conformations of higher gangliosides (GD3, GT1a. GT1b, GQ1b) have been determined by computing their potential energy using semi-empirical potential functions. The favoured conformation of the disialic acid fragment in these gangliosides is independent of its position (internal or terminal). The favoured conformations of these gangliosides have also been correlated to their biological activity. The results suggest that tetanus toxin and sendai virus may have a large binding site which can accommodate at least four sugar residues.

Item Type: Journal Article
Publication: Carbohydrate Polymers
Publisher: Elsevier Science
Additional Information: Copyright for this article belongs to Elsevier Science.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 29 Jan 2010 05:33
Last Modified: 19 Sep 2010 05:41
URI: http://eprints.iisc.ac.in/id/eprint/22342

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