Probing into the role of conserved N-glycosylation sites in the Tyrosinase glycoprotein family

Gupta, Garima and Sinha, Sharmistha and Mitra, Nivedita and Surolia, Avadhesha (2009) Probing into the role of conserved N-glycosylation sites in the Tyrosinase glycoprotein family. In: 8th International Symposium on Cell Surface Macromolecules, 2008, Hyderabad, INDIA, pp. 691-695.

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Abstract

N-linked glycosylation has a profound effect on the proper folding, oligomerization and stability of glycoproteins. These glycans impart many properties to proteins that may be important for their proper functioning, besides having a tendency to exert a chaperone-like effect on them. Certain glycosylation sites in a protein however, are more important than other sites for their function and stability. It has been observed that some N-glycosylation sites are conserved over families of glycoproteins over evolution, one such being the tyrosinase related protein family. The role of these conserved N-glycosylation sites in their trafficking, sorting, stability and activity has been examined here. By scrutinizing the different glycosylation sites on this family of glycoproteins it was inferred that different sites in the same family of polypeptides can perform distinct functions and conserved sites across the paralogues may perform diverse functions.

Item Type:	Conference Paper
Publication:	Glycoconjugate Journal
Publisher:	Springer
Additional Information:	copyright of this article belongs to Sprigner.
Keywords:	N-linked glycosylation; Tyrosinase; TRP-1; TRP-2
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	23 Dec 2009 09:25
Last Modified:	19 Sep 2010 05:41
URI:	http://eprints.iisc.ac.in/id/eprint/22273

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