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DNA structural variability as a factor in gene expression and evolution

Conrad, Michael and Brahmachari, SK and Sasisekharan, V (1986) DNA structural variability as a factor in gene expression and evolution. In: Biosystems, 19 (2). pp. 123-126.

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Redundant DNA can buffer sequence dependent structural deviations from an ideal double helix. Buffering serves a mechanistic function by reducing extraneous conformational effects which could interfere with readout or which would impose energetic constraints on evolution. It also serves an evolutionary function by allowing for gradual variations in conformation-dependent regulation of gene expression. Such gradualism is critical for the rate of evolution. The buffer structure concept provides a new interpretation for repetitive DNA and for exons and introns.

Item Type: Journal Article
Publication: Biosystems
Publisher: Elsevier Science
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Redundant DNA;Introns;DNA evolution.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 03 Jul 2009 10:21
Last Modified: 19 Sep 2010 05:36
URI: http://eprints.iisc.ac.in/id/eprint/21177

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