Vijayakumar, EKS and Balaram, P (1983) Solution conformations of penta and heptapeptides containing repetitive α-aminoisobutyryl-Image -alanyl and α -aminoisobutyryl-Image -valyl sequences. In: Tetrahedron, 39 (16). pp. 2725-2731.
PDF
sdarticle.pdf - Published Version Restricted to Registered users only Download (584kB) | Request a copy |
Abstract
The presence of folded solution conformations in the peptides Boc-Ala-(Aib-Ala)2-OMe, Boc-Val-(Aib-Val) 2-OMe, Boc-Ala-(Aib-Ala)3-OMe and Boc-Val-(Aib-Val)3-OMe has been established by 270MHz 1H NMR. Intramolecularly H-bonded NH groups have been identified using temperature and solvent dependence of NH chemical shifts and paramagnetic radical induced broadening of NH resonances. Both pentapeptides adopt 310 helical conformations possessing 3 intramolecular H-bonds in CDCl3 and (CD3)2SO. The heptapeptides favour helical structures with 5 H-bonds in CDCl3. In (CD3)2SO only 4 H-bonds are readily detected.
Item Type: | Journal Article |
---|---|
Publication: | Tetrahedron |
Publisher: | Elsevier Science |
Additional Information: | Copyright of this article belongs to Elsevier Science |
Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit |
Date Deposited: | 04 Feb 2010 07:08 |
Last Modified: | 19 Sep 2010 05:32 |
URI: | http://eprints.iisc.ac.in/id/eprint/20418 |
Actions (login required)
View Item |