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Critical Cation Balance In B-]Z Transition - Role Of Li+

Ramesh, N and Bramachari, SK (1983) Critical Cation Balance In B-]Z Transition - Role Of Li+. In: FEBS Letters, 164 (1). 33-37.

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The sodium salt of poly(dG-dC) is known to exhibit a B + Z transition in the presence of various cations and 60% alcohol. We here show that the lithium salt of poly(dG-dC) does not undergo B 4 Z transition in the presence of 60% alcohol since Li’ with its large hydration shell cannot stabilize the Z-form. On the other hand, high concentrations of Mg2* or micromolar concentrations of the cobalt hexamine complex which are known to stabilize the Z-form can compete with Li+ for charge neutraIization and hence bring about a B--t Z transition in the same polymer. From the model building studies the mode of action of the cobalt-hexamine complex in stabilizing the Z-form is postulated.

Item Type: Journal Article
Publication: FEBS Letters
Publisher: EIsevier Science
Additional Information: Copyright of this article belongs to EIsevier Science.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 30 May 2009 05:56
Last Modified: 19 Sep 2010 05:32
URI: http://eprints.iisc.ac.in/id/eprint/20203

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