Brahmachari, SK and Ramesh, N and Das, MR and Parnaik, VK (1985) Poly(dG-dC) in the Z-form inhibits E. coli DNA polymerase I and AMV DNA polymerase activity. In: Biochemistry International, 11 (13). pp. 281-290.
Full text not available from this repository. (Request a copy)Abstract
The effect of Z-conformation of DNA on its template activity in DNA synthesis reactions in vitro has been studied. Normal poly(dG-dC) in the B-form, brominated and unbrominated in the Z-form have been compared for their template activity in DNA synthesis reactions mediated by AMV DNA polymerase and E. coli DNA polymerase I. The results indicate that poly(dG-dC) in the Z-form is totally inactive as a template for DNA synthesis and further that it is a strong competitive inhibitor of copying of the B-form DNA.
| Item Type: | Journal Article |
|---|---|
| Publication: | Biochemistry International |
| Publisher: | American Chemical Society |
| Additional Information: | Copyright of this article belongs to American Chemical Society. Biochemistry International currently does not have a website |
| Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit Division of Biological Sciences > Biochemistry |
| Date Deposited: | 04 Jul 2008 |
| Last Modified: | 27 Aug 2008 13:32 |
| URI: | http://eprints.iisc.ac.in/id/eprint/14751 |
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